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Tregs can also induce apoptosis in a perforin-dependent manner via granzymes A and B (201, 203207)

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RNA-seq profiling confirmed that MEC-1/N M cells recapitulate the metabolic and proliferative transcriptional programs identified in unstimulated primary CLL/N M samples and demonstrated that these pathways are further reinforced upon 24-h -IgM stimulation in the MEC-1 model (Supplementary Fig

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We demonstrated that Aldh2 KI mice carrying the East Asian-specific Glu504Lys mutation were more prone to develop diet-induced obesity, fatty liver, insulin resistance and glucose intolerance than WT mice Importantly, the ALDH2 activator AD-9308 increased both the catalytic activity of WT and mutant enzyme, reduced serum 4-HNE levels, and effectively alleviated diet-induced obesity, fatty liver, insulin resistance, and glucose intolerance in both Aldh2 KI and WT mice in a dose-dependent manner

Deletion of aldose reductase from mice inhibits diabetesinduced retinal capillary degeneration and superoxide generation