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Endothelial cells that have been stimulated and are in an activated state have the ability to generate various signalling molecules such as cytokines, chemokines, and growth factors

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Laloux, C

This approach has been used to show that proteasome concentrations in peripheral blood are elevated in patients with certain types of malignant diseases, including multiple myeloma, suggesting that circulating proteasome levels may be correlated with tumour burden