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CJC-1295 or the placebo was administered subcutaneously in one of four ascending single doses in the first study and in two or three weekly or biweekly doses in the second study

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All statistical tests were two-sided and used a significance level of P 4000 observations additionally including an additional sample with data collected in subjects still available at 6-year follow-up

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It acts as a cofactor for lysyl oxidase, the enzyme that crosslinks new collagen and elastin into stable matrix

The Jarisch-Herxheimer reaction: revisited