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Mechanistically, the phagocytosis of apoptotic podocyte debris by macrophages triggers the activation of the NLRP3 inflammasome, which in turn promotes the maturation of IL-1 and IL-18, thereby establishing a podocyte-macrophage interactive damage cycle (35)

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Its likely that a combination of factors is at play. MS-specific studies, including one published in February 2026 on PubMed Central , say that low sun exposure, Vitamin D deficiency, using tobacco, lack of exercise, and obesity are some of the leading causes of MS onset

To be published