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Purity grade matters significantly for GI and neural research designs because copper-contaminated or low-purity batches introduce confounding variables that make mechanistic interpretation unreliable

10.1523/JNEUROSCI.3207-04.2004 28 BossertJ

Vandetanib Vandetanib (Caprelsa ) is an oral small-molecule inhibitor of VEGFR-2, VEGFR-3, EGFR, and RET ( Axitinib Axitinib (Inlyta ) is an oral second-generation pan-VEGFR TKI (Tyler, 2012)

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Sci Rep 8:9101 Imae M, Fu Z, Yoshida A, Noguchi T, Kato H (2003) Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16