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Isothiocyanate quinazolinone derivatives inhibit U251 glioma cell proliferation through cell cycle regulation and apoptosis induction

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ASCT2 is overexpressed on the surface of various tumor cells, such as gastric cancer (Ma et al., 2021), colon cancer (Ma et al., 2018), pancreatic cancer (Wang et al., 2022), and TNBC (Van Geldermalsen et al., 2016)

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Recombinant yeast tests further affirmed the role of SjGSTs in stress resistance

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(Accessed March 12, 2025)

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J Affect Disord (2012) 143:1605.10.1016/j.jad.2012.05.047 6 De DiosCGonzlez-PintoAMontesJMGoikoleaJMSaiz-RuizJPrietoEet alPredictors of recurrence in bipolar disorders in Spain (PREBIS study data)

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The compound has been in pre-clinical investigation for decades

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