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DR is conventionally divided into several phases: the preclinical phase represented by non-proliferative DR (NPDR

Thus, both through direct and indirect actions, cytokines have a profound effect on systemic metabolism and the development of sickness behavior

Neutrophil Akt2 plays a critical role in heterotypic neutrophil-platelet interactions during vascular inflammation

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This inhibition reduces the antioxidant capacity of cells, leading to an accumulation of ROS, causing further damage to cellular components and expediting cellular aging (Tan et al., 2020)

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