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It is forbidden to appoint to females during pregnancy and lactation, at essential disturbances of development of cartilaginous fabric, defeats of a nervous system which are followed by spasms, and also at allocation from the patient of the animal microorganisms steady against fluoroquinolones

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[7] Niacin can cause vasodilation, so it should be avoided in those with serious hypotension

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Moreover, when the research was conducted on isolated bovine chondrocytes, it appeared that there might be an increased production of proteoglycan and collagen