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However, there have been increasing reports of clinical cases of regurgitation and/or aspiration of gastric contents during induction of general anesthesia and extubation

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In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist

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This agent works as a purine nucleoside phosphorylase inhibitor, a different mechanism than any of the medications to chronically lower uric acid described above

The role of peptide therapeutics in longevity and age-related disease.Nature Reviews Drug Discovery, 21(8), 579598