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Unfolding of mucins is dependent on concentrations of bicarbonate, calcium, and sodium in the airway with high concentrations of extracellular calcium, acidic pH, or hyperabsorption of sodium preventing unfolding of the gel-forming mucins (Kesimer et al., 2010

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Drug compounding defined by the FDA as the process of combining, mixing or altering ingredients of a drug to create a medication tailored to a patients needs was the primary way drugs were produced until large-scale pharmaceutical manufacturing emerged early in the 20th century

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