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Conclusion In conclusion, this systematic review demonstrates that the APOE4 genotype in mice is associated with compromised blood-brain barrier integrity, reflected by consistent pathogenic alterations in vascular morphology, cerebral blood flow dynamics, and mechanistic pathways linking ECM remodelling, junctional instability and metabolic dysregulation

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Hantikainen, E.M

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Mechanisms of toxic action and structure-activity relationships for organochlorine and synthetic pyrethroid insecticides