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Although crocin showed poor absorption and limited BBB permeability, it demonstrated higher aqueous solubility and was neither a substrate nor inhibitor of major CYP450 enzymes, indicating a low risk of metabolic interactions

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Additionally, this enzyme is involved in cancer cell metabolism, survival, angiogenesis, and chemoresistance (19)

These results are consistent with previous reports 49 , UVB irradiation induced increased expression of pro-apoptotic proteins Bax and caspase-3 in concert with the repression of antiapoptotic proteins Bcl-2, while accompanied by collagen loss and an increase of MMPs

Lu B, Chen XB, Hong YC, Zhu H, He QJ, Yang B, et al

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