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Research has demonstrated that celastrol induces paraptosis in breast cancer cells via the IP3R-dependent Ca 2+ signalling pathway, highlighting the critical role of Ca 2+ homeostasis disruption in this death pattern [124]
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The N-terminal acetylation confers enhanced proteolytic stability and improved bioavailability compared to unmodified sequences

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Witko-SarsatVFriedlanderMCapeillre-BlandinCNguyen-KhoaTNguyenAZingraffJet alAdvanced oxidation protein products as a novel marker of oxidative stress in uremia