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Interestingly, through effects on the hypothalamus and vagus nerve (gastric), apoA-IV also serves as a mediator of satiety and appetite [41]

However, the specific metabolite exerting this effect was not identified 41

[DOI] [PMC free article] [PubMed] [Google Scholar] Rosenwasser AM (2001) Alcohol, antidepressants, and circadian rhythms
The serum marker has been seen to be associated with disease severity and so is deemed the most useful biomarker for mitochondrial diseases [27]

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