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Bacterial metabolites, especially SCFAs, influence enteric neurotransmission, neuroplasticity, and neural circuit development

EXAMPLES: Andarine, Ostarine SIDE EFFECTS: Testicular shrinkage, liver injury and failure, infertility, sexual dysfunction, sleep disturbances, and increased risk of heart attack and stroke

A recent review of positron emission tomography (PET) studies with opioid receptor-specific tracers posit a central role of the opioid system for positive affective states (Nummenmaa & Tuominen, 2017)

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