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Selecting an appropriate coumarin-based matrix depends on the properties of the sample and the desired analytical outcomes

doi: 10.3389/fmicb.2023.1290441 18 DiaoJ.HuY.TianY.CarrR.MoonT

doi: 10.1056/NEJM196310102691501 49 Ouled-HaddouH.MessaoudiK.DemontY.SantosR

Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function

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Future research should aim to unravel the precise molecular pathways underlying the observed effects, evaluate long-term outcomes, and investigate the applicability of these results in human populations