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The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action

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[DOI] [PubMed] [Google Scholar] Sato H, Tamba M, Okuno S, Sato K, Keino-Masu K, Masu M, et al

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