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Mitochondria in ME/CFS The mitochondria are best known for oxidizing metabolic substrates and using oxidative phosphorylation for generating the high energy molecule adenosine triphosphate (ATP), but it also performs many other activities critical for maintaining cellular homeostasis (114)

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651 The Keap1-Nrf2 pathway has been described as the primary protective response to oxidative and electrophilic stress 652 and is often disrupted in oncogenic process

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