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Strikingly, a higher percentage of keratinocytes showing nuclear AIFM1 staining was found in lesional skin from psoriasis patients compared with healthy skin (Fig 7C and 7D)

However, clinical translation faces several challenges: difficulties in large-scale production of complex nanostructures requiring precise control of layered compositions (118), systemic oxidative damage (e.g., hepatotoxicity) caused by free iron ions (137), long-term retention issues of certain metal nanoparticles (138), potential complement system activation or inflammatory responses triggered by nanoparticles (139) and limited delivery efficiency due to tumor stromal barriers and immunosuppressive TME (140)

PMC 3151730

A Persulfide Donor Responsive to Reactive Oxygen Species: Insights into Reactivity and Therapeutic Potential

10.1186/s13018-020-1551-9 246 TranP

In writing the peptide structure, the amino terminal (N-terminal) amino acid is written first and carboxyl terminal (C-terminal) amino acid written last