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Collectively, these data indicate that the significantly reduced Aldh2 activity of Aldh2 KI mice results in elevated toxic aldehydes levels and, especially 4-HNE and increased 4-HNE adduction to proteins involved in mitochondrial reduced FAO and mitochondrial respiration of BAT, leading to markedly decreased FAO rate and mitochondrial respiration and subsequent reduced adaptive thermogenesis and energy expenditure

doi: 10.1016/j.molimm.2018.01.014

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The efficiency and integrity of the lung structure, phagocytes and mucociliary clearance are crucial, as an impairment in the function and structure can lead to respiratory conditions such as asthma, COPD and cystic fibrosis (Munkholm and Mortensen 2014)