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Main documentation is based on in vitro and preclinical data A variety of microorganisms including bacteria (e.g., Clostridium difficile 157 ), archaea (e.g., Methanococcus jannaschii 158 ), fungi (e.g., Eremothecium ashbyii 159 , Saccharomyces cerevisiae 160 ) have a documented capacity to produce riboflavin at different levels 40,161 , although in general, under physiological conditions the microbial riboflavin production is very low (few g/L, or less, in culture media)

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