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Evidence from clinical trials has validated riluzoles effectiveness in extending median survival of ALS patients by two to three months and slowing the decline in respiratory capabilities, a significant marker of ALS progression (25)

206 Combined administration of shikonin and cisplatin increases Fe 2+ , ROS, and lipid peroxidation (LPO) levels and downregulates GPX4 in ovarian cancer cells, reducing cisplatin resistance by inducing ferroptosis

2 g in WT mice (Fig

Therefore, some scholars have proposed the concept of "glutamine hijacking," which suggests that targeted inhibition of glutamine metabolism in tumor cells can alleviate glutamine competition in the tumor microenvironment, release glutamine for immune cell utilization, and promote anti-tumor immune response [134]

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