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Following the inhibition of ceramide biosynthesis, several mechanisms would be correlated with oxidative stress and apoptosis due to immunolocalization of the lower doses of FB 1 in specific targets, such as mitochondria and nucleus (Figure 1) (101)

This approach is crucial for maintaining the therapys effectiveness

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[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Gyimesi G., Hediger M.A

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However, the presence of methyl parathion reduces the activity rate of tyrosinase and slows down the quenching process