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Yu J, Dong XD, Jiao JS, Ji HY, Liu AJ

Biochimica et Biophysica Acta (BBA) General Subjects

Recently, Nestin expression has been identified in bone marrow MSCs (27), which may be genetically marked to trace their fate

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For instance, individuals carrying polymorphisms in the deiodinase type 2 gene (DIO2), such as the common Thr92Ala variant, have an altered enzymatic activity and impaired T3 generation at the tissue level, potentially explaining the limited clinical response to LT4 monotherapy in these patients (1416)

ISRCTN59922389) , a pragmatic phase IV randomized controlled trial, is currently investigating the optimization of long-term azithromycin treatment to further refine prevention strategies for exacerbations