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In addition, several GPX4-independent anti-ferroptosis pathways have recently been identified, such as the apoptosis-inducing factor mitochondria-associated 2 (AIFM2)-mediated CoQ10 production pathway ( FIGURE 1 Lipid peroxidation results in the oxidation of polyunsaturated fatty acid (PUFA) of the membrane lipids

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Qi, C., Chen, Y., Huang, J.-H., Jin, Q.-Z

138 KaczmarczykODbek-DrobnyAPitek-GuziewiczAWoniakiewiczMPakoPDobrowolska-IwanekJet al

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The treatment of rats with aqueous Jamun seed extract and polymeric nanoparticles formulated from the seed extract administered once daily for 21 subsequent days significantly attenuated the inflammatory cytokines TNF-, interferon gamma, dipeptidyl peptidase IV, IL1, and IL6 and elevated the anti-inflammatory cytokine IL10