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Further, while adoptive transfer experiments showed that D5 signaling drives T reg suppressive functions, in nave CD4 + T-cells, D5 signaling increased proliferation and increased the differentiation of the T h 17 inflammatory phenotype in the early stages of EAE (Osorio-Barrios et al., 2018)

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Chin Med 21 , 25 (2026)

*Correspondence: Xiaoyu Wang, [email protected]

Preclinical studies investigating the use of Fer-1 to treat h-ARS, RIII, and RILI all found that the drug imparted protective effects against ferroptosis and IR damage [67, 105, 108]

Moreover, peptides have the ability to target specific flat pockets on molecules, areas that are considered unreachable by conventional small-molecule drugs