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A PD-L1 antibody-conjugated PAMAM dendrimer nanosystem for simultaneously inhibiting glycolysis and promoting immune response in fighting breast cancer

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Mutation and copy number discordance in primary versus metastatic colorectal cancer (mCRC)

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High levels of sugar in the blood (hyperglycemia) and insulin deficiency or resistance can lead to increased oxidative stress

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doi: 10.1038/s41556-018-0178-0

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Gut dysbiosis is a disruption in healthy gut microbial balance, promoting CRC through inflammation, impaired barrier function, and altered nutrient processing and mucosal integrity

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This pattern mirrors what researchers see with semaglutide GI side effects and tirzepatide GI side effects

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