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FGF21 has originally been described as a fasting hormone that is upregulated in the liver via PPAR and partly regulates ketogenesis during starvation or KDs

1) Clinical research on any further neurodegenerative conditions outside AD 2) Cell-line research, in silico investigations, experiments with experimental fish, non-rodent studies, and any other study using animals, except rats and mice 3) Results unrelated to AD, such as pathology 4) Societies with comorbidities 5) Interventional research involving any other toxicants besides MSG, combined with any other toxicants, was excluded from the review 2.4 Data extraction The team of raters independently extracted the data from the included research

used multi-drug resistance protein 2 knockout (MDR2-KO) mice as PSC models and analyzed liver tissues and hepatocyte extracts from wild-type mice

2022 Sep;150(3):727-735.e6

Yet, in the body, (1) -tocopherol is preferentially retained in the liver by the binding to -tocopherol transfer protein (-TTP), which incorporates -tocopherol into lipoproteins for delivery to extrahepatic tissues

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