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The nasal delivery route has been studied as an alternative to subcutaneous injection
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On the other hand, due to the efflux of FC, when macrophages accumulate a large amount of FC, it is a powerful apoptosis inducer, which will lead to the release of intracellular contents and thrombosis (37)
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To understand the structural basis of this abnormal binding characteristic, Sack et al solved the crystal structure of the wild-type (WT) (PDB: 1I37) and T877A (PDB: 1I38) AR LBDs complexed with DHT 67
