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Higher is not always better: 9 mg often delivers a better efficacy-to-tolerability ratio than 12 mg

& Porta, C

Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: A drug discovery effort against alzheimer's disease

While a 2014 pooled analysis of seven RCTs concluded neither benefits nor harms of the supplementation in patients with heart failure [126], the 1993 and 2020 RCTs supported the supplementations benefit on improved endothelial function, reduced hospitalization, and reduced serious complications in patients with heart failure [127,128]

This enormous safety margin explains why serious adverse effects remain essentially unreported in the research literature

Much of the peptide can be destroyed before it ever reaches the intestines where it could be absorbed
