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Several RCTs investigating vitamin K supplementation, particularly with K1 or low-dose K2 (e.g., MK-4), have failed to show significant reductions in vascular calcification or improvement in insulin sensitivity

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J Physiol 594(7):18551873 Saraulli D, Costanzi M, Mastrorilli V, Farioli-Vecchioli S (2017) The long run: neuroprotective effects of physical exercise on adult neurogenesis from youth to old age

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Through its effects on the metabolism of catecholamine neurotransmitters and estrogen, COMT is emerging as a key player in the pathogenesis of AD

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