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The acetyl-CoA enters the Krebs cycle and together with oxaloacetate give rise to citrate, which can be exported to the cytoplasm and engage in NADPH-producing reactions: the transformation of malate to pyruvate catalyzed by malic enzyme (ME1) and the oxidation of isocitrate into -ketoglutarate catalyzed by isocitrate dehydrogenase (IDH1)

10.1172/jci23621 32 EberlD.HegartyB.BossardP.FerrP.FoufelleF

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Because of the extensive literature on mice models of AD, a review article on this topic alone could be justified