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[91] found that early-life fisetin administration enhanced glucose metabolism, cognitive function, and reduced SASP expression in male mice, indicating sex-dependent responses to preventive interventions

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Histological and 8-OHdG immunohistochemical studies were preformed on 12 weeks from the beginning of treatment

Weigand-Heller AJ, Kris-Etherton PM & Beelman RB (2012) The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation