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According to the glutamate hypothesis, dysfunction of NMDA receptormediated neurotransmission has been implicated in the pathophysiology of negative symptoms in schizophrenia (Hu et al

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16 These impaired DNA modifications can accelerate aging and cause neurodegenerative, carcinogenesis, autoimmune, cardiovascular, and other diseases

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In Figure5 we show the millimoles of APAP, APAP-S, and APAP-G that accumulate in the urine over a 24-hour period in the model for a range of doses