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Data interpretation

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Alterations in expression of dopamine receptors and neuropeptides in the striatum of GTP cyclohydrolase-deficient mice

The dysfunction present with these conditions includes down regulation of D1 (reduced T4 to T3 conversion) and reduced uptake of T4 into the cell, resulting in increased serum T4 levels with low intracellular T3 levels and upregulated D3, resulting in elevated reverse T3,which blocks the thyroid effect and is an indicator of reduced transport of T4 into the cell

and E.L.) based on blind assessment

2021;7:eabi8193