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Studies have found that Epitalon restored melatonin formation in the pineal body of older monkeys, increased superoxide dismutase (SOD) activity, and reduced the amount of LPO products, diene conjugates, and ROS [23, 33, 34]

Shamekhi MA, Mirzadeh H, Mahdavi H, Rabiee A, Mohebbi-Kalhori D, Baghaban Eslaminejad M

For human relevance, controlled trials with clear endpoints are the critical step

Thus, a higher Bcl-2/Bax ratio is posted as a predominance of Bcl-2, which may inhibit apoptosis and apparently promotes cell survival

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