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Heliyon 8:e11632

A phase 1 trial included 4 ROR1 -positive TNBC patients who had undergone at least three-line treatments and received ROR1 -targeted CAR-T therapy, 2 individuals showed stable disease, and one participant had a partial response after the second infusion, persisting for 14 weeks

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This leads to their clustering and activation, which also induces a conformational change [42,43]

Zafereo ME , Iyer P
