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490,491,492,493,494,495 Rapamycin, which is used clinically under the generic name sirolimus or marketed under the brand name rapamune by Pfizer and Novartis, was the first drug developed to inhibit mTOR, followed by several analogs that constitute first-generation mTOR inhibitors (Fig

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In the fibrotic lung, activation of PI3K/Akt promotes EMT, enhances fibroblast survival, and stimulates ECM production, thereby exacerbating fibrosis progression (Qian et al., 2018)

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