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Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program

More specifically, physiological levels of copper are necessary for hemoglobin synthesis, drug and xenobiotic metabolism, carbohydrate intermediary metabolism, catecholamine biosynthesis, collagen cross-linking, hair keratin formation, and metabolic processes enabling antioxidant defense [27,33]

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These differences may have resulted in a relative reduction in effect sizes when pooling cross-sectional estimates obtained in the main analyses and those from 6-year follow-up analyses