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This suggests that amino acid metabolism is sensitive to specific changes of the TCA cycle and that regulation of amino acid metabolism is adjusted according to this specific change

Moreover, one of the major advantages of miRNA therapy is simultaneously targeting multiple effectors in several signaling pathways involved in tumorigenesis

There were inhibited mRNA of inflammatory mediators (iNOS, IL-6, IFN and TNF-), increased expression of HSP 70 and 90, and antioxidant proteins, such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2 and GST-pi [30]