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12 Although these compounds are beneficial in the free form, it was also confirmed that when bound to lens proteins, as occurs with increasing age in the lens nucleus, these UV filters become stronger photosensitizers which can, in the presence of oxygen and UV radiation, generate singlet oxygen, superoxide anion, and hydrogen peroxide within the lens nucleus 24 Hydrogen peroxide, although producing little direct damage, can be converted into highly reactive and damaging species in the presence of transition metals

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Mechanistic data across tumor-cell, endothelial, neuronal and myeloid compartments support therapeutic interrogation of these axes, with fusion-directed TRK inhibition as standard of care where applicable and biomarker-guided investigation of pathway blockade in the broader population

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