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Bright-field imaging was performed with a white light-emitting diode

Excessive depletion of oxidants may result in the induction of reductive stress, characterized by declined physiological functions, such as suppressed mitochondrial function, cell proliferation, the occurrence of cardiomyopathies, and other pathologies (Rajasekaran et al

however, the identified hits need to be confirmed in functional assays in order to prove the inhibiting activity on NOX2

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Mechanistically, these effects correlate with an upsurge of reactive oxygen species (ROS), initiating oxidative stress and directly damaging genomic DNA