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A: Hexarelin's hexapeptide binding geometry activates GHS-R1a at pituitary corticotroph and adrenal cell populations in addition to somatotrophs

Eid, R., Arab, N.T.T., Greenwood, M.T

Cell Death Dis (2011) 2:e240.10.1038/cddis.2011.117 81 WangS-JWuW-MYangF-LHsuG-SWHuangC-Y

A study in healthy adults showed that oral glucose loading reduced GH response to GHRH by 75% compared to fasted conditions (Giustina & Veldhuis, Endocr Rev 1998)

One hundred and eighty-one patients with diabetes who received oral ALA or placebo once daily were enrolled: 45 patients received ALA 600 mg, 47 patients received ALA 1200 mg, and 46 patients received ALA 1800 mg