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Other indirect ways to stimulate the antiepileptic effects of KD may lay in the alterations of the metabolism of neurotransmitters such as glutamate and gamma-amino butyric acid (GABA), and the activation of energy-sensing signaling pathways such as the PPAR, mammalian target of rapamycin (mTOR), and adenosine monophosphate-(AMP)-activated kinase (AMPK) pathways (71, 72)

PMID: 29550383

Roberts, LJ, 2nd

J.HoffmanK

A high disease incidence of CUD (~1 in 40,000) was confirmed in Taiwan where NBS for fatty acid oxidation defect (FAOD) had been started in 2002

Choline, as a precursor of PC, a major component of lung surfactants, may help compensate for eosinophilic phospholipases-pulmonary surfactant dysfunction in asthma, thereby reducing airway inflammation and disease severity (95)