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Description
the ability of cells to metabolize -Glu-Met)
Njoo et al., 2015)
Mechanistically, this combination suppresses EGFR activity by disrupting the interaction between Sp1 and HADC1 and inhibits the ERK/MEK and AKT/S6K pathways, contributing to the induction of autophagy [259]
T.GalloR
Since GPX4 relies on GSH to neutralize lipid peroxides, lactate-driven metabolic reprogramming may indirectly compromise GPX4 efficiency, rendering PASMCs more susceptible to ferroptotic stimuli
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