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This gap between extensive animal research and limited human clinical data characterizes the current state of BPC-157 science

Toxicol., 4: 808-818

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Due to the global opioid crisis, the judicious use of chronic opioids is advised and only after informed decision-making with the patients and with periodic follow-ups to assess efficacy, adverse side effects, compliance, and potential of abuse or misuse

And that was a surprise that it took that extra shot, because the initial data was so promising