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The Development Candidate molecule is brain penetrant, orally bioavailable, and has demonstrated favorable safety margins in non-GLP studies

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sodium chloride, mannitol, This unit dosage form may further contain pharmaceutically acceptable excipients such as polyethylene glycol 400 or dextran

Such ligand-induced dimerization model has been observed in the activation of c-MET by a bacterial c-MET agonistInlB 31 , as well as in the activation of many other RTKs, such as PDGFR and VEGFR 32,33