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Auditory Brainstem Response (ABR) assessmentDuring the procedure, additional anesthetic (xylazine and ketamine) is administered if needed to maintain the depth of anesthesia sufficient to insure immobilization and relaxation

Tissue injury was evaluated microscopically by a blinded examiner

Preclinical cartilage evidence Kwon and Park 2015 in Annals of Clinical and Laboratory Science reported that intra-articular AOD-9604 plus hyaluronic acid in a rabbit knee osteoarthritis model improved cartilage histology and reduced lameness compared with hyaluronic acid alone

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Not like the typical 2 or 3 days of discomfort published by Pfizer