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2020;318:E1116
The NAD+-driven increase in cellular energetics can amplify stimulant effects, producing jitteriness or insomnia if dosed too late in the day
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Some patients have also experienced a hypersensitivity reaction following intramuscular injection that has resulted in anaphylactic shock and death
For Lebers optic atrophy or smokers blindness, the usual dose starts at 1000mcg, given daily for 2 weeks, followed by twice weekly
