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Clinical studies and preclinical models suggest that Tim-3-expressing macrophages, whose renal expression correlates with the severity of diabetic nephropathy, induce podocyte injury through the NF-B/Tumor necrosis factor-alpha (TNF-) pathway, with reduced nephrin expression being inversely associated with macrophage activation (34)

Coniferyl ferulate can alleviate the toxicity of xylene to hematopoietic stem and progenitor cells by targeting Mgst2

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Suskind AM, Berry SH, Ewing BA et al: The prevalence and overlap of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome in men: Results of the rand interstitial cystitis epidemiology male study

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